| Title |
Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally
|
|---|---|
| Published in |
Radiology, August 2016
|
| DOI | 10.1148/radiol.2016161584 |
| Pubmed ID | |
| Authors |
Patricia Soares de Oliveira-Szejnfeld, Deborah Levine, Adriana Suely de Oliveira Melo, Melania Maria Ramos Amorim, Alba Gean M Batista, Leila Chimelli, Amilcar Tanuri, Renato Santana Aguiar, Gustavo Malinger, Renato Ximenes, Richard Robertson, Jacob Szejnfeld, Fernanda Tovar-Moll |
| Abstract |
Purpose To document the imaging findings associated with congenital Zika virus infection as found in the Instituto de Pesquisa in Campina Grande State Paraiba (IPESQ) in northeastern Brazil, where the congenital infection has been particularly severe. Materials and Methods From June 2015 to May 2016, 438 patients were referred to the IPESQ for rash occurring during pregnancy or for suspected fetal central nervous system abnormality. Patients who underwent imaging at IPESQ were included, as well as those with documented Zika virus infection in fluid or tissue (n = 17, confirmed infection cohort) or those with brain findings suspicious for Zika virus infection, with intracranial calcifications (n = 28, presumed infection cohort). Imaging examinations included 12 fetal magnetic resonance (MR) examinations, 42 postnatal brain computed tomographic examinations, and 11 postnatal brain MR examinations. Images were reviewed by four radiologists, with final opinion achieved by means of consensus. Results Brain abnormalities seen in confirmed (n = 17) and presumed (n = 28) congenital Zika virus infections were similar, with ventriculomegaly in 16 of 17 (94%) and 27 of 28 (96%) infections, respectively; abnormalities of the corpus callosum in 16 of 17 (94%) and 22 of 28 (78%) infections, respectively; and cortical migrational abnormalities in 16 of 17 (94%) and 28 of 28 (100%) infections, respectively. Although most fetuses underwent at least one examination that showed head circumference below the 5th percentile, head circumference could be normal in the presence of severe ventriculomegaly (seen in three fetuses). Intracranial calcifications were most commonly seen at the gray matter-white matter junction, in 15 of 17 (88%) and 28 of 28 (100%) confirmed and presumed infections, respectively. The basal ganglia and/or thalamus were also commonly involved with calcifications in 11 of 17 (65%) and 18 of 28 (64%) infections, respectively. The skull frequently had a collapsed appearance with overlapping sutures and redundant skin folds and, occasionally, intracranial herniation of orbital fat and clot in the confluence of sinuses. Conclusion The spectrum of findings associated with congenital Zika virus infection in the IPESQ in northeastern Brazil is illustrated to aid the radiologist in identifying Zika virus infection at imaging. (©) RSNA, 2016 Online supplemental material is available for this article. |
X Demographics
The data shown below were collected from the profiles of 108 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 31 | 29% |
| United Kingdom | 6 | 6% |
| Canada | 6 | 6% |
| Spain | 4 | 4% |
| Brazil | 4 | 4% |
| Australia | 3 | 3% |
| Mexico | 3 | 3% |
| Ireland | 2 | 2% |
| France | 2 | 2% |
| Other | 11 | 10% |
| Unknown | 36 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 73 | 68% |
| Practitioners (doctors, other healthcare professionals) | 17 | 16% |
| Scientists | 12 | 11% |
| Science communicators (journalists, bloggers, editors) | 6 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 369 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | <1% |
| New Zealand | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 364 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 54 | 15% |
| Student > Master | 52 | 14% |
| Student > Bachelor | 48 | 13% |
| Student > Doctoral Student | 36 | 10% |
| Student > Ph. D. Student | 28 | 8% |
| Other | 85 | 23% |
| Unknown | 66 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 134 | 36% |
| Agricultural and Biological Sciences | 33 | 9% |
| Neuroscience | 29 | 8% |
| Biochemistry, Genetics and Molecular Biology | 26 | 7% |
| Immunology and Microbiology | 14 | 4% |
| Other | 56 | 15% |
| Unknown | 77 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1459. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2019.
All research outputs
#8,344
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Outputs from Radiology
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Outputs of similar age
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Outputs of similar age from Radiology
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